Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8919071 | 0.78 | EIF4A3 (0.54) | GABRA1GABRB1EIF4A3THRB | |
| SCHEMBL8919857 | 0.75 | CA12 (0.55) | GABRA1GABRB1GABRB2EIF4A3CA12 | |
| SCHEMBL7264698 | 0.74 | DAO (0.41) | CA12CA9DAOMAPTHCAR1 | |
| SCHEMBL8922856 | 0.73 | EIF4A3 (0.40) | GABRA1GABRB1EIF4A3CA12CA9 | |
| SCHEMBL29241812 | 0.73 | CA12 (0.56) | CA12CA9DAOMAPTHCAR1 | |
| SCHEMBL21133726 | 0.69 | CA12 (0.52) | EIF4A3CA12CA9DAOCHEK1 | |
| SCHEMBL19737508 | 0.68 | CA12 (0.50) | EIF4A3CA12CA9MAPTTHRB | |
| SCHEMBL14828635 | 0.68 | CA12 (0.54) | EIF4A3CA12CA9DAOMAPT | |
| SCHEMBL20125007 | 0.68 | CA12 (0.50) | EIF4A3CA12CA9DAOMAPT | |
| SCHEMBL19737431 | 0.67 | ADORA3 (0.43) | CA12CA9METMAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4710507-A | Quinolone inotropic agents | PFIZER INC. (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0148623-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1985-07-17 | — | — | EP | disclosed |