Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | MC1R | Q01726 | 2/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265280 | 0.86 | F2 (0.53) | MC4RALDH1A1CYP3A4CYP2C19F2 | |
| SCHEMBL8633510 | 0.86 | F2 (0.53) | MC4RALDH1A1CYP3A4CYP2C19F2 | |
| SCHEMBL7265407 | 0.80 | DPP4 (0.53) | P2RX7DPP4MC4RMC1RMC3R | |
| SCHEMBL7276202 | 0.80 | HRH3 (0.48) | ALDH1A1SMN1; SMN2F2POLBMEN1 | |
| SCHEMBL7286910 | 0.80 | PKM (0.53) | EPHX2TSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL7272882 | 0.80 | HRH3 (0.48) | ALDH1A1SMN1; SMN2F2POLBMEN1 | |
| SCHEMBL7274839 | 0.80 | PKM (0.53) | EPHX2TSHRALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL3681344 | 0.71 | POLB (0.58) | P2RX7DPP4MC4RMC1RMC3R | |
| SCHEMBL7284471 | 0.71 | DPP4 (0.47) | DPP4PREPTSHRMEN1KMT2A | |
| SCHEMBL7282828 | 0.70 | F2 (0.56) | ALDH1A1CYP3A4CYP2C19F2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0268190-B1 | PROLINAL DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | claimed |