Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | PREP | P48147 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | MC1R | Q01726 | 2/20 | 0.44 |
| ▸ | MC3R | P41968 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266965 | 0.85 | PKM (0.55) | SMN1; SMN2MEN1KMT2APKM | |
| SCHEMBL7275011 | 0.85 | NPC1 (0.54) | PKM | |
| SCHEMBL7266943 | 0.84 | DPP4 (0.56) | DPP4GAAMEN1KMT2A | |
| SCHEMBL7275293 | 0.83 | LMNA (0.45) | DPP4PREPGAA | |
| SCHEMBL7284471 | 0.83 | DPP4 (0.47) | DPP4PREPTSHRHDAC1HDAC8 | |
| SCHEMBL7272118 | 0.82 | KDM4E (0.52) | GAAMEN1KMT2APKM | |
| SCHEMBL7316783 | 0.82 | P2RX7 (0.43) | DPP4PREPP2RX7HDAC1HDAC8 | |
| SCHEMBL7265335 | 0.80 | P2RX7 (0.50) | DPP4PREPP2RX7MC4RMC1R | |
| SCHEMBL7265331 | 0.79 | KMT2A (0.46) | DPP4PREPMEN1KMT2A | |
| SCHEMBL7267106 | 0.79 | TP53 (0.59) | DPP4P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | claimed |
| EP-0268190-B1 | PROLINAL DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| EP-0268190-A1 | Prolinal derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-05-25 | — | — | EP | claimed |
| US-5340832-A | Prolinal derivatives useful for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-08-23 | — | — | US | disclosed |
| US-5254550-A | Enzyme inhibitor | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-10-19 | — | — | US | disclosed |
| US-5100904-A | Inhibition of prolyl endopeptidase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |