Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 17/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7265449 | 0.84 | ACE (0.86) | ACEABCB11LMNA | |
| SCHEMBL7270118 | 0.79 | CTSK (0.46) | — | |
| SCHEMBL10959654 | 0.78 | ACE (0.73) | ACEABCB11 | |
| Imidapril SCHEMBL7354516 | 0.76 | ACE (1.00) | ACEABCB11LMNA | |
| Imidapril SCHEMBL22492310 | 0.76 | ACE (1.00) | ACEABCB11LMNA | |
| Imidapril SCHEMBL3193644 | 0.76 | ACE (1.00) | ACEABCB11LMNA | |
| Imidapril SCHEMBL6516062 | 0.76 | ACE (1.00) | ACEABCB11LMNA | |
| Imidapril SCHEMBL11014327 | 0.76 | ACE (1.00) | ACEABCB11LMNA | |
| Imidapril SCHEMBL34098 | 0.76 | ACE (1.00) | ACEABCB11LMNA | |
| Imidapril SCHEMBL12894585 | 0.76 | ACE (1.00) | ACEABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508727-A | Antihypertensive 2-oxo-imidazolidine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1985-04-02 | — | — | US | disclosed |
| EP-0095163-A2 | 2-Oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition | Tanabe Seiyaku Co., Ltd. (JP) | 1983-11-30 | — | — | EP | disclosed |