Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11845098 | 0.86 | KDM4E (0.62) | KDM4ENR4A2HPGDSMN1; SMN2LMNA | |
| SCHEMBL7267240 | 0.84 | CHRM1 (0.55) | KDM4ENR4A2HPGDSMN1; SMN2LMNA | |
| SCHEMBL2845353 | 0.84 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL9193870 | 0.77 | RXRA (0.51) | KDM4ENR4A2HPGDSMN1; SMN2MAPT | |
| SCHEMBL9518314 | 0.76 | ADORA3 (0.56) | KDM4EHPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL7272062 | 0.76 | KDM4E (0.49) | KDM4EHPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1927942 | 0.75 | KDM4E (0.54) | KDM4EHPGDSMN1; SMN2LMNAALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL27564581 | 0.75 | ADORA3 (0.55) | KDM4EHPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL11147319 | 0.75 | KDM4E (0.56) | KDM4ENR4A2HPGDSMN1; SMN2LMNA | |
| SCHEMBL11839513 | 0.75 | KDM4E (0.55) | KDM4EHPGDSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028991-C | Tetrahydronaphthalene derivatives | HOFFMANN LA ROCHE (CH) | 1995-06-21 | — | — | CN | disclosed |
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |
| CN-87107875-A | TETRAHYDRONAPHTHALENE DERIVATIVES | — | 1988-05-25 | — | — | CN | disclosed |