Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | C5 | P01031 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193870 | 0.88 | RXRA (0.51) | CHRM1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL2845353 | 0.84 | KDM4E (0.47) | KDM4EKMT2AMEN1HPGDLMNA | |
| SCHEMBL7265476 | 0.84 | KDM4E (0.60) | KDM4EKMT2AMEN1HPGDLMNA | |
| SCHEMBL11147319 | 0.84 | KDM4E (0.56) | KDM4EKMT2AMEN1HPGDLMNA | |
| SCHEMBL9518314 | 0.79 | ADORA3 (0.56) | KDM4EHPGDLMNAPTGS1PTGS2 | |
| SCHEMBL31106525 | 0.78 | KDM4E (0.55) | KDM4EKMT2AMEN1HPGDLMNA | |
| SCHEMBL11848374 | 0.78 | ALDH1A1 (0.52) | KDM4EKMT2AMEN1HPGDLMNA | |
| SCHEMBL9267822 | 0.78 | KDM4E (0.50) | KDM4EKMT2AMEN1HPGDLMNA | |
| Ammonia Solution, Strong SCHEMBL27564581 | 0.78 | ADORA3 (0.55) | KDM4EHPGDLMNAPTGS1PTGS2 | |
| SCHEMBL9194841 | 0.77 | TGFBR1 (0.47) | KMT2AMEN1RXRAMAPK1RXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028991-C | Tetrahydronaphthalene derivatives | HOFFMANN LA ROCHE (CH) | 1995-06-21 | — | — | CN | disclosed |
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |
| CN-87107875-A | TETRAHYDRONAPHTHALENE DERIVATIVES | — | 1988-05-25 | — | — | CN | disclosed |