Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | SELE | P16581 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8678351 | 0.88 | ALDH1A1 (0.51) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL4367931 | 0.82 | SIRT2 (0.53) | ALDH1A1LMNAMEN1KMT2ACHEK2 | |
| SCHEMBL6631157 | 0.81 | CHEK2 (0.54) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL7264564 | 0.80 | CHEK2 (0.45) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL5326846 | 0.77 | HPGD (0.56) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL2850866 | 0.77 | BCL2L1 (0.51) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL29503125 | 0.76 | AR (0.53) | PARP1 | |
| SCHEMBL11761622 | 0.74 | MEN1 (0.60) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL1149093 | 0.74 | PDE7A (0.85) | KDM4EMAPTHPGDALDH1A1LMNA | |
| SCHEMBL2790717 | 0.72 | HSD11B1 (0.45) | CHEK2PARP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151529-B1 | 5-(AMINO OR SUBSTITUTED AMINO)-1,2,3-TRIAZOLES | MERCK & CO. INC. (US) | 1991-09-18 | — | — | EP | disclosed |
| US-4590201-A | ANTICOCCIDIAL AGENT FOR ANIMALS PARTICULARLY FOR POULTRY | MERCK & CO., INC. (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0151529-A2 | 5-(Amino or substituted amino)-1,2,3-triazoles | MERCK & CO. INC. (US) | 1985-08-14 | — | — | EP | disclosed |