Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.45 |
| ▸ | METAP2 | P50579 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304096 | 0.81 | REN (0.50) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7358175 | 0.80 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL7431264 | 0.75 | METAP1 (0.46) | RENMETAP2METAP1 | |
| SCHEMBL7266293 | 0.74 | METAP2 (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7266597 | 0.74 | METAP2 (0.41) | RENMETAP2METAP1 | |
| SCHEMBL7266321 | 0.74 | METAP2 (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7264762 | 0.74 | METAP2 (0.41) | RENMETAP2METAP1 | |
| SCHEMBL3719549 | 0.73 | METAP2 (0.50) | RENMETAP2METAP1 | |
| SCHEMBL3719547 | 0.73 | METAP2 (0.50) | RENMETAP2METAP1 | |
| SCHEMBL7852214 | 0.73 | METAP2 (0.50) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |