Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266321 | 1.00 | METAP2 (0.44) | METAP2METAP1RENSLC1A3SLC1A2 | |
| SCHEMBL7264762 | 0.77 | METAP2 (0.41) | METAP2METAP1REN | |
| SCHEMBL7266597 | 0.77 | METAP2 (0.41) | METAP2METAP1REN | |
| SCHEMBL3719549 | 0.76 | METAP2 (0.50) | METAP2METAP1RENCYP1A2 | |
| SCHEMBL3719547 | 0.76 | METAP2 (0.50) | METAP2METAP1RENCYP1A2 | |
| SCHEMBL7852214 | 0.76 | METAP2 (0.50) | METAP2METAP1RENCYP1A2 | |
| SCHEMBL7266557 | 0.74 | REN (0.45) | METAP2METAP1REN | |
| SCHEMBL7283383 | 0.74 | METAP1 (0.42) | METAP2METAP1RENCYP1A2 | |
| SCHEMBL13724320 | 0.71 | METAP1 (0.58) | METAP2METAP1CYP1A2 | |
| SCHEMBL17613550 | 0.71 | METAP1 (0.48) | METAP2METAP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |