Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 3/20 | 0.62 |
| ▸ | ABL1 | P00519 | 3/20 | 0.62 |
| ▸ | BCR | P11274 | 3/20 | 0.62 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.61 |
| ▸ | PRKCG | P05129 | 2/20 | 0.61 |
| ▸ | PRKCB | P05771 | 2/20 | 0.61 |
| ▸ | PRKCH | P24723 | 2/20 | 0.61 |
| ▸ | PRKCI | P41743 | 2/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.61 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952360 | 0.87 | ZAP70 (0.68) | PRKCAABL1ZAP70PRKD3PRKCG | |
| SCHEMBL6957800 | 0.86 | ZAP70 (0.66) | PRKCAZAP70PRKD3PRKCGPRKCB | |
| SCHEMBL6952728 | 0.85 | ZAP70 (0.65) | PRKCAZAP70PRKD3PRKCGPRKCB | |
| SCHEMBL6955195 | 0.85 | ZAP70 (0.67) | PRKCAABL1BCRZAP70PRKD3 | |
| SCHEMBL6947468 | 0.85 | CAMK2D (0.72) | PRKCAABL1BCRZAP70PRKD3 | |
| SCHEMBL6955868 | 0.85 | ZAP70 (0.61) | PRKCAABL1BCRZAP70PRKD3 | |
| Dimethylamine SCHEMBL7267011 | 0.84 | ZAP70 (0.68) | PRKCAABL1ZAP70PRKD3PRKCG | |
| SCHEMBL6947682 | 0.83 | ZAP70 (0.72) | PRKCAZAP70PRKD3PRKCGPRKCB | |
| SCHEMBL6952361 | 0.82 | PRKCA (0.63) | PRKCAABL1BCRZAP70PRKD3 | |
| SCHEMBL6950853 | 0.81 | ZAP70 (0.66) | PRKCAZAP70PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552029-B1 | For therapy of rheumatoid arthritis, psoriasis, graft v. host disease, asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, complications following percutaneous transluminal coronary angioplasty, thrombosis | CELLTECH R&D LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |
| US-6114333-A | 2-Pyrimidineamine derivatives and processes for their preparation | CELLTECH THERAPEUTICS LTD. (GB) | 2000-09-05 | — | — | US | disclosed |
| EP-0934304-A1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998018782-A1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-05-07 | — | — | WO | disclosed |