Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | PTGIR | P43119 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | LOX | P28300 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835692 | 0.87 | PKM (1.00) | PKMGAARAPGEF4HSD11B1AKR1B1 | |
| SCHEMBL14486413 | 0.87 | PKM (1.00) | PKMGAARAPGEF4HSD11B1AKR1B1 | |
| SCHEMBL13074716 | 0.87 | PKM (1.00) | PKMGAARAPGEF4HSD11B1AKR1B1 | |
| SCHEMBL19008825 | 0.81 | PKM (0.86) | PKMGAARAPGEF4SMN1; SMN2HSD11B1 | |
| SCHEMBL17472319 | 0.81 | PKM (0.86) | PKMGAARAPGEF4SMN1; SMN2HSD11B1 | |
| SCHEMBL18069681 | 0.81 | PKM (0.86) | PKMGAARAPGEF4SMN1; SMN2HSD11B1 | |
| SCHEMBL14148915 | 0.81 | PKM (0.86) | PKMGAARAPGEF4SMN1; SMN2HSD11B1 | |
| SCHEMBL13665511 | 0.79 | PKM (0.83) | PKMGAARAPGEF4CYP2C9CYP2C19 | |
| SCHEMBL825670 | 0.79 | PKM (0.83) | PKMGAARAPGEF4CYP2C9CYP2C19 | |
| SCHEMBL2900381 | 0.79 | PKM (0.83) | PKMGAARAPGEF4SMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302793-B1 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| US-5215988-A | Treating angina, hypertension, arrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-06-01 | — | — | US | disclosed |
| US-5182291-A | Angina pectoris, hypotensive, antiarrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-01-26 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5039700-A | Cardiovascular disorders, antitumor agents | SANOFI (FR) | 1991-08-13 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4994474-A | Hypotensive agents | SANOFI (FR) | 1991-02-19 | — | — | US | disclosed |
| US-4957925-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS, TREATMENT OF ANGINA | SANOFI (FR) | 1990-09-18 | — | — | US | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302793-A2 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | ELF SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |