Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 8/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275269 | 0.99 | LMNA (0.62) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL891476 | 0.88 | MEN1 (0.63) | LMNAALDH1A1MAPTHPGDTSHR | |
| Hydrochloric Acid SCHEMBL7266437 | 0.87 | MEN1 (0.61) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL8132581 | 0.84 | RAB9A (0.68) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL11139092 | 0.84 | RAB9A (0.68) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL25315525 | 0.84 | RAB9A (0.68) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL30947438 | 0.83 | LMNA (0.78) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL10540636 | 0.82 | LMNA (0.57) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL1838349 | 0.82 | RAB9A (0.70) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7267151 | 0.81 | DAO (0.47) | LMNAALDH1A1MAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028991-C | Tetrahydronaphthalene derivatives | HOFFMANN LA ROCHE (CH) | 1995-06-21 | — | — | CN | disclosed |
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |
| CN-87107875-A | TETRAHYDRONAPHTHALENE DERIVATIVES | — | 1988-05-25 | — | — | CN | disclosed |