Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267288 | 0.81 | LMNA (0.61) | MAPTTSHRMAPK1HTTALDH1A1 | |
| SCHEMBL7275269 | 0.80 | LMNA (0.62) | MAPTTSHRMAPK1HTTALDH1A1 | |
| SCHEMBL891430 | 0.76 | DAO (0.55) | DAOMAPTTSHRMAPK1HTT | |
| SCHEMBL2270268 | 0.76 | CYP1A2 (0.60) | DAOTSHRLMNASMN1; SMN2RAB9A | |
| SCHEMBL738662 | 0.76 | DAO (0.51) | DAOMAPTTSHRMAPK1HTT | |
| SCHEMBL3286243 | 0.71 | DAO (0.69) | DAOLMNAPGR | |
| SCHEMBL891476 | 0.69 | MEN1 (0.63) | MAPTTSHRMAPK1HTTALDH1A1 | |
| SCHEMBL2173962 | 0.68 | DAO (0.49) | DAO | |
| SCHEMBL2482082 | 0.68 | NAAA (0.46) | DAOLMNASMN1; SMN2 | |
| SCHEMBL8247664 | 0.68 | ADORA3 (0.51) | DAOMAPTTSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 1991-12-11 | — | — | EP | disclosed |
| US-4808605-A | Tetrahydronaphthalene derivatives as calcium antagonists | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |