Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | STAT6 | P42226 | 1/20 | 0.63 |
| ▸ | NTSR1 | P30989 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266516 | 0.90 | KDM4E (0.64) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| SCHEMBL7262669 | 0.88 | KDM4E (0.76) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| SCHEMBL7267813 | 0.86 | ALDH1A1 (0.70) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7266340 | 0.86 | SMN1; SMN2 (0.67) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| SCHEMBL7261986 | 0.84 | NPSR1 (0.47) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| SCHEMBL7268570 | 0.84 | KDM4E (0.60) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| SCHEMBL4091890 | 0.83 | NPSR1 (0.57) | NPSR1KDM4ESTAT6ALDH1A1SMN1; SMN2 | |
| SCHEMBL7261541 | 0.82 | KDM4E (0.57) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7268677 | 0.80 | KDM4E (0.64) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 | |
| SCHEMBL7261513 | 0.80 | TSHR (0.57) | NPSR1KDM4ESTAT6NTSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613772-B1 | Drugs such as 2-(p-chlorophenyl-4-(4-hydroxybutyl)amino-6,7,8 -trimethoxyquinazoline used for activation of guanylate cyclase and modulation of cyclic guanosine monophosphate | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-09-02 | — | — | US | disclosed |
| EP-1040101-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032460-A1 | SUBSTITUTED 2-ARYL-4-AMINO-CHINAZOLINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-01 | — | — | WO | disclosed |