Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.36 |
| ▸ | TUBB | P07437 | 4/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267245 | 1.00 | KDM4E (0.42) | KDM4EHPGDALDH1A1MAPTNPSR1 | |
| SCHEMBL7267242 | 1.00 | KDM4E (0.42) | KDM4EHPGDALDH1A1MAPTNPSR1 | |
| SCHEMBL7267092 | 0.72 | STING1 (0.42) | KDM4EHPGDTUBB4ATUBBTUBA3C | |
| SCHEMBL7276014 | 0.72 | STING1 (0.42) | KDM4EHPGDTUBB4ATUBBTUBA3C | |
| SCHEMBL7267085 | 0.72 | STING1 (0.42) | KDM4EHPGDTUBB4ATUBBTUBA3C | |
| SCHEMBL5545117 | 0.71 | KDM4E (0.39) | KDM4EHPGDALDH1A1MAPTTUBB4A | |
| SCHEMBL9808648 | 0.70 | CA2 (0.47) | KDM4EHPGDALDH1A1MAPTCYP1A2 | |
| SCHEMBL27984914 | 0.67 | KDM4E (0.55) | KDM4EHPGDALDH1A1MAPTGAA | |
| SCHEMBL7274175 | 0.67 | BACE1 (0.53) | KDM4EALDH1A1MAPTTUBB4ATUBB | |
| SCHEMBL7274183 | 0.67 | BACE1 (0.53) | KDM4EALDH1A1MAPTTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352832-B1 | COMPOUNDS WITH BRONCHODILATOR ACTIVITY | AKZO N.V. (NL) | 1992-05-06 | — | — | EP | disclosed |
| US-5026724-A | Benzothiophene derivatives | AKZO N.V. (NL) | 1991-06-25 | — | — | US | disclosed |
| EP-0352832-A1 | Compounds with bronchodilator activity | AKZO N.V. (NL) | 1990-01-31 | — | — | EP | disclosed |