Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 12/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274183 | 1.00 | BACE1 (0.53) | BACE1CLK1DYRK1ADYRK1BCA2 | |
| SCHEMBL7275954 | 1.00 | BACE1 (0.53) | BACE1CLK1DYRK1ADYRK1BCA2 | |
| SCHEMBL9808648 | 0.88 | CA2 (0.47) | BACE1CA2KMT2AKDM4EL3MBTL1 | |
| SCHEMBL2633018 | 0.79 | CYP2A6 (0.62) | BACE1CLK1DYRK1ADYRK1BCA2 | |
| SCHEMBL31697962 | 0.79 | CYP2A6 (0.62) | BACE1CLK1DYRK1ADYRK1BCA2 | |
| SCHEMBL7267085 | 0.78 | STING1 (0.42) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7267092 | 0.78 | STING1 (0.42) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7276014 | 0.78 | STING1 (0.42) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16693089 | 0.76 | TUBB4A (0.46) | DYRK1ACA2TUBB4ATUBBTUBA3C | |
| SCHEMBL16693044 | 0.73 | CYP2A6 (0.58) | CA2TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352832-B1 | COMPOUNDS WITH BRONCHODILATOR ACTIVITY | AKZO N.V. (NL) | 1992-05-06 | — | — | EP | disclosed |
| US-5026724-A | Benzothiophene derivatives | AKZO N.V. (NL) | 1991-06-25 | — | — | US | disclosed |
| EP-0352832-A1 | Compounds with bronchodilator activity | AKZO N.V. (NL) | 1990-01-31 | — | — | EP | disclosed |