SCHEMBL7268166

SCHEMBL7268166

O=C(Nc1cc2ccccc2cc1C(=O)O)OCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.61
PTPN1 P18031 1/20 0.57
NPC1 O15118 2/20 0.57
RAB9A P51151 2/20 0.57
ABCC1 P33527 1/20 0.53
PLAU P00749 1/20 0.53
MAPT P10636 3/20 0.51
GFER P55789 1/20 0.51
NGLY1 Q96IV0 1/20 0.51
MGLL Q99685 1/20 0.51
CTSV O60911 2/20 0.51
CTSL P07711 2/20 0.51
TACR3 P29371 1/20 0.51
ALDH1A1 P00352 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HPGD P15428 1/20 0.50
AKR1C3 P42330 1/20 0.50
AKR1C2 P52895 1/20 0.50
AKR1C1 Q04828 1/20 0.50
HSD17B10 Q99714 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3496550 0.84 NPC1 (0.58) MAOBNPC1RAB9APLAUGFER
SCHEMBL27060882 0.83 CTSV (0.56) MAOBNPC1RAB9AMAPTMGLL
SCHEMBL27485037 0.83 NPC1 (0.66) MAOBNPC1RAB9APLAUMGLL
SCHEMBL2233522 0.83 NPC1 (0.69) MAOBPTPN1NPC1RAB9AABCC1
SCHEMBL10489859 0.82 KDM4E (0.60) NPC1RAB9AMAPTGFERCTSV
SCHEMBL1131165 0.82 CASP3 (0.61) NPC1RAB9AMGLLKDM4EAKR1C3
SCHEMBL26030821 0.82 CASP3 (0.62) MAOBNPC1RAB9APLAUMAPT
SCHEMBL8479003 0.81 CASP3 (0.62) NPC1RAB9AALDH1A1KDM4EL3MBTL1
SCHEMBL10163089 0.81 KMT2A (0.58) MAOBNPC1RAB9APLAUMGLL
SCHEMBL692063 0.81 MAOB (0.58) MAOBPTPN1NPC1RAB9APLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0839137-B1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LAB (IT) 2001-08-16 EP disclosed
US-5922875-A ANTIULCER AGENTS, ANTITUMOR AGENTS TREATING GASTROINTESTINAL DISORDER, CENTRAL NERVOUS SYSTEM DISORDER LINKED TO IMBALANCES IN THE NEURAL PHYSIOLOGICAL LEVELS OF GASTRIN OR OTHER BIOACTIVE POLYPEPTIDES, EYE INFLAMMATION CAUSED BY SURGERY ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1999-07-13 US disclosed
EP-0839137-A1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1998-05-06 EP disclosed
US-5652369-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1997-07-29 US disclosed
US-5620987-A Amino acid derivatives HOFFMANN-LA ROCHE INC. (US) 1997-04-15 US disclosed
WO-1997002248-A1 AROMATIC ACID DIAMIDES WITH ANTIGASTRIN ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ROTTA RESEARCH LABORATORIUM S.P.A. (IT) 1997-01-23 WO disclosed
US-5554756-A PROTEASE INHIBITOR HOFFMANN-LA ROCHE INC. (US) 1996-09-10 US disclosed
US-5446161-A Protease inhibitor, viricides HOFFMANN-LA ROCHE INC. (US) 1995-08-29 US disclosed
EP-0346847-B1 Amino acid derivatives HOFFMANN LA ROCHE (CH) 1994-05-11 EP disclosed
WO-1993020099-A2 CCK AND/OR GASTRIN RECEPTOR LIGANDS FERRING B.V. (NL) 1993-10-14 WO disclosed
US-5157041-A Viricides HOFFMANN-LA ROCHE INC. (US) 1992-10-20 US disclosed
EP-0346847-A2 Amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1989-12-20 EP disclosed