Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LONP1 | P36776 | 4/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.40 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.40 |
| ▸ | PSMB3 | P49720 | 3/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.40 |
| ▸ | PSMA6 | P60900 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268186 | 1.00 | REN (0.47) | RENPSMB5BACE1LONP1PSMB11 | |
| SCHEMBL7277900 | 0.83 | REN (0.47) | RENBACE1 | |
| SCHEMBL7277916 | 0.83 | REN (0.47) | RENBACE1 | |
| SCHEMBL7277290 | 0.76 | REN (0.61) | REN | |
| SCHEMBL7277296 | 0.76 | REN (0.61) | REN | |
| SCHEMBL7269158 | 0.76 | REN (0.44) | RENPSMB5BACE1LONP1PSMB11 | |
| SCHEMBL7269155 | 0.76 | REN (0.44) | RENPSMB5BACE1LONP1PSMB11 | |
| SCHEMBL7317387 | 0.74 | REN (0.53) | REN | |
| SCHEMBL7316242 | 0.74 | REN (0.53) | REN | |
| SCHEMBL7315458 | 0.74 | REN (0.53) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |