Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.41 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269155 | 1.00 | REN (0.44) | RENMMP2MMP3MMP7PTPRB | |
| SCHEMBL7269941 | 0.93 | CTSD (0.43) | RENMMP2MMP3MMP7PTPRB | |
| SCHEMBL7275145 | 0.85 | REN (0.47) | RENMMP2MMP3MMP7PSMB5 | |
| SCHEMBL7275153 | 0.85 | REN (0.47) | RENMMP2MMP3MMP7PSMB5 | |
| SCHEMBL7267680 | 0.82 | REN (0.45) | RENPTPRBPSMB5BACE1 | |
| SCHEMBL7270164 | 0.81 | REN (0.52) | REN | |
| SCHEMBL7278774 | 0.81 | REN (0.43) | RENPSMB5BACE1 | |
| SCHEMBL7278777 | 0.81 | REN (0.43) | RENPSMB5BACE1 | |
| SCHEMBL7268405 | 0.79 | MME (0.59) | MMP2MMP7 | |
| SCHEMBL7268401 | 0.79 | MME (0.59) | MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2215798-A | — | — | None | — | — | JP | disclosed |
| JP-H02215798-A | RENIN INHIBITOR | AMERICAN CYANAMID CO | 1990-08-28 | — | — | JP | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |