Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277916 | 1.00 | REN (0.47) | RENLTA4HBACE1BACE2OPRM1 | |
| SCHEMBL7269900 | 0.84 | REN (0.49) | RENLTA4HBACE1BACE2OPRM1 | |
| SCHEMBL7269905 | 0.84 | REN (0.49) | RENLTA4HBACE1BACE2OPRM1 | |
| SCHEMBL7268182 | 0.83 | REN (0.47) | RENBACE1 | |
| SCHEMBL7268186 | 0.83 | REN (0.47) | RENBACE1 | |
| SCHEMBL7275153 | 0.82 | REN (0.47) | RENLTA4HBACE1BACE2OPRM1 | |
| SCHEMBL7275145 | 0.82 | REN (0.47) | RENLTA4HBACE1BACE2OPRM1 | |
| SCHEMBL30051506 | 0.78 | LTA4H (0.72) | LTA4HOPRM1OPRD1OPRK1MME | |
| SCHEMBL7076107 | 0.78 | LTA4H (0.61) | LTA4HOPRK1MME | |
| SCHEMBL30051692 | 0.77 | LTA4H (0.67) | LTA4HMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |