Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.51 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 5/20 | 0.43 |
| ▸ | NOS1 | P29475 | 5/20 | 0.43 |
| ▸ | NOS2 | P35228 | 5/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269272 | 1.00 | TAS1R3 (0.51) | TAS1R3TAS1R1BIRC2POLBNOS3 | |
| SCHEMBL15107083 | 0.88 | SMN1; SMN2 (0.49) | TAS1R3TAS1R1BIRC2SMN1; SMN2CASP1 | |
| SCHEMBL2402155 | 0.87 | ALDH1A1 (0.51) | FOLH1CASP1ALDH1A1 | |
| SCHEMBL8951293 | 0.87 | ALDH1A1 (0.51) | FOLH1CASP1ALDH1A1 | |
| SCHEMBL15106970 | 0.84 | SMN1; SMN2 (0.41) | TAS1R3TAS1R1SMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL28385473 | 0.83 | CASP1 (0.43) | SMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL10535408 | 0.83 | CASP1 (0.43) | SMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL28387010 | 0.83 | CASP1 (0.43) | SMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL9047102 | 0.82 | TAS1R3 (0.52) | TAS1R3TAS1R1BIRC2POLBNOS3 | |
| SCHEMBL9052342 | 0.81 | TAS1R3 (0.40) | TAS1R3TAS1R1BIRC2POLBFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4977272-A | Radiation absorbers | THE STANDARD OIL COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| US-4868061-A | ADDITION POLYMERS, ULTRAVIOLET RADIATION STABILIZERS | THE STANDARD OIL COMPANY (US) | 1989-09-19 | — | — | US | disclosed |