Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073853 | 0.79 | KMT2A (0.48) | ALDH1A1KMT2AMEN1HTR2AHTR2C | |
| SCHEMBL30882012 | 0.79 | PARP10 (0.53) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL4715588 | 0.79 | PARP10 (0.53) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL25687365 | 0.76 | HTR2C (0.45) | ALDH1A1HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL7048326 | 0.75 | KMT2A (0.45) | ALDH1A1KMT2AMEN1HTR2AHTR2C | |
| SCHEMBL5564105 | 0.73 | MAOA (0.49) | ALDH1A1KMT2AMEN1HTR2AHTR2C | |
| SCHEMBL3369853 | 0.72 | MAPT (0.60) | ALDH1A1KMT2AMEN1HTR2AHTR2C | |
| SCHEMBL3369857 | 0.72 | MAPT (0.60) | ALDH1A1KMT2AMEN1HTR2AHTR2C | |
| SCHEMBL7853515 | 0.72 | KMT2A (0.50) | ALDH1A1KMT2AMEN1HTR2AHTR2C | |
| SCHEMBL31619838 | 0.72 | MAPT (0.60) | ALDH1A1KMT2AMEN1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370381-B1 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4988698-A | Cardiovascular disorders, hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0370381-A2 | 2(1H)-quinolinone compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-30 | — | — | EP | disclosed |