Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 3/20 | 0.38 |
| ▸ | METAP1 | P53582 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 8/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269543 | 1.00 | POLB (0.39) | POLBEPHX2METAP2METAP1CTSK | |
| SCHEMBL7299275 | 1.00 | POLB (0.39) | POLBEPHX2METAP2METAP1CTSK | |
| SCHEMBL7269925 | 1.00 | POLB (0.39) | POLBEPHX2METAP2METAP1CTSK | |
| SCHEMBL7269929 | 1.00 | POLB (0.39) | POLBEPHX2METAP2METAP1CTSK | |
| SCHEMBL7269548 | 1.00 | POLB (0.39) | POLBEPHX2METAP2METAP1CTSK | |
| SCHEMBL7269271 | 1.00 | POLB (0.39) | POLBEPHX2METAP2METAP1CTSK | |
| SCHEMBL7316703 | 0.77 | POLB (0.43) | POLBEPHX2CTSKGCKCNR2 | |
| SCHEMBL7316693 | 0.77 | POLB (0.43) | POLBEPHX2CTSKGCKCNR2 | |
| SCHEMBL7424256 | 0.75 | REN (0.41) | METAP2METAP1CTSKGCKCNR2 | |
| SCHEMBL9740699 | 0.75 | REN (0.41) | METAP2METAP1CTSKGCKCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |