Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 8/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316703 | 1.00 | POLB (0.43) | POLBEPHX2CNR2CTSKGCK | |
| SCHEMBL9705262 | 0.83 | REN (0.46) | POLBCNR2CTSKKCNH2 | |
| SCHEMBL9705257 | 0.83 | REN (0.46) | POLBCNR2CTSKKCNH2 | |
| SCHEMBL9740697 | 0.82 | REN (0.41) | CNR2CTSKGCK | |
| SCHEMBL7424256 | 0.82 | REN (0.41) | CNR2CTSKGCK | |
| SCHEMBL9740699 | 0.82 | REN (0.41) | CNR2CTSKGCK | |
| SCHEMBL7269773 | 0.78 | CTSC (0.38) | POLBEPHX2CTSKGCKKCNH2 | |
| SCHEMBL7269778 | 0.78 | CTSC (0.38) | POLBEPHX2CTSKGCKKCNH2 | |
| SCHEMBL15689096 | 0.78 | ADAM17 (0.41) | TSHRADAM17 | |
| SCHEMBL7424258 | 0.77 | CCR1 (0.40) | POLBEPHX2CNR2CTSKGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |