Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.58 |
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | PDE6D | O43924 | 1/20 | 0.58 |
| ▸ | PDE8A | O60658 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | PDE9A | O76083 | 1/20 | 0.58 |
| ▸ | PDE8B | O95263 | 1/20 | 0.58 |
| ▸ | PDE6A | P16499 | 1/20 | 0.58 |
| ▸ | PDE6G | P18545 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE6B | P35913 | 1/20 | 0.58 |
| ▸ | PDE6C | P51160 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.58 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268354 | 0.90 | PDE3B (0.62) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL971019 | 0.89 | PDE3B (0.61) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL7270195 | 0.79 | PDE4A (0.61) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL175950 | 0.75 | PDE2A (1.00) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL29236885 | 0.73 | PIK3CD (0.51) | PDE3BPDE3AOPRM1OPRD1OPRK1 | |
| SCHEMBL21676438 | 0.70 | OPRM1 (0.52) | PDE3BPDE3AOPRM1OPRD1OPRK1 | |
| SCHEMBL971482 | 0.69 | PSMB1 (0.45) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL10739858 | 0.68 | KIF11 (0.56) | PDE3BPDE3AMEN1KMT2AHSD17B10 | |
| SCHEMBL10743990 | 0.68 | KDM4E (0.53) | PDE3BPDE3AMEN1KMT2AHSD17B10 | |
| SCHEMBL6307136 | 0.66 | KDM4E (0.60) | MEN1KMT2AHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400583-B1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LAB (US) | 1999-11-17 | — | — | EP | claimed |
| US-5055465-A | IMIDAZOQUINOXALINONES, THEIR AZA ANALOGS AND PROCESS FOR THEIR PREPARATION | BERLEX LABORATORIES, INC. (US) | 1991-10-08 | — | — | US | claimed |
| EP-0400583-B1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LAB (US) | 1999-11-17 | — | — | EP | disclosed |
| US-5166344-A | Process for the preparation of imidazoquinoxalinones | BERLEX LABORATORIES, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5055465-A | IMIDAZOQUINOXALINONES, THEIR AZA ANALOGS AND PROCESS FOR THEIR PREPARATION | BERLEX LABORATORIES, INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0400583-A1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LABORATORIES, INC. (US) | 1990-12-05 | — | — | EP | disclosed |