Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | FCER2 | P06734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727512 | 0.91 | MME (0.47) | — | |
| SCHEMBL9875926 | 0.90 | ALDH1A1 (0.53) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL9875934 | 0.90 | ALDH1A1 (0.53) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL9551315 | 0.85 | ALDH1A1 (0.49) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL7332377 | 0.85 | REN (0.46) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL9800625 | 0.85 | REN (0.46) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL7321074 | 0.84 | BIRC2 (0.47) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL9665739 | 0.83 | ALDH1A1 (0.45) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL9551271 | 0.83 | ALDH1A1 (0.53) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL10436047 | 0.83 | OPRK1 (0.55) | BIRC2ALDH1A1THRBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389616-A | Renin inhibitor, hypotensive agent | HOFFMAN-LAROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5256645-A | Renin inhibitors; hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5140011-A | Hypotensive agents | HOFFMANN-LA ROCHE, INC. (US) | 1992-08-18 | — | — | US | disclosed |
| US-5134123-A | Renin enzyme inhibitors for cardiovascular disorders and high blood pressure | HOFFMAN-LA ROCHE INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0391180-A2 | Peptide derivatives of amino acids having a renin-inhibiting effect | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |