Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | MPI | P34949 | 1/20 | 0.73 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031919 | 0.85 | ALDH1A1 (0.79) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL26367831 | 0.85 | KDM4E (0.92) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10679583 | 0.85 | KDM4E (1.00) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL28772805 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL9052405 | 0.80 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL31001020 | 0.80 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL26367873 | 0.80 | KDM4E (0.70) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL24174147 | 0.79 | GPR84 (0.53) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL28346139 | 0.79 | MEN1 (0.50) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL28404785 | 0.79 | MEN1 (0.53) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630597-B1 | Photochromic 6-aryl substituted 3H-naphtho(2, 1-b)pyran compounds, examples of which are naphthopyran compounds having a substituted aryl group at the number 6 carbon atom and certain substituents at the 3-position of the pyran ring | TRANSITIONS OPTICAL, INC. | 2003-10-07 | — | — | US | disclosed |
| EP-1042311-A1 | PHOTOCHROMIC 6-ARYL SUBSTITUTED 3H-NAPHTHO 2,1-b]PYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031082-A1 | PHOTOCHROMIC 6-ARYL SUBSTITUTED 3H-NAPHTHO[2,1-b]PYRANS | TRANSITIONS OPTICAL, INC. (US) | 1999-06-24 | — | — | WO | disclosed |