Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.40 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.39 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.39 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.39 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.39 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.39 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274796 | 0.98 | REN (0.46) | RENOPRK1HSPA5HSPA2LTA4H | |
| SCHEMBL7269901 | 0.80 | REN (0.56) | RENCCKBR | |
| SCHEMBL9813890 | 0.75 | POLB (0.57) | RENLTA4HPOLBMAPTATM | |
| SCHEMBL7274802 | 0.75 | MMP2 (0.36) | RENHSPA5HSPA2LTA4HPOLB | |
| SCHEMBL7275145 | 0.74 | REN (0.47) | RENOPRK1HSPA5HSPA2LTA4H | |
| SCHEMBL7275153 | 0.74 | REN (0.47) | RENOPRK1HSPA5HSPA2LTA4H | |
| SCHEMBL30051506 | 0.72 | LTA4H (0.72) | OPRK1LTA4H | |
| SCHEMBL7076107 | 0.72 | LTA4H (0.61) | OPRK1LTA4H | |
| SCHEMBL7269897 | 0.71 | POLB (0.37) | RENPOLBMAPTATMNPSR1 | |
| SCHEMBL30051692 | 0.71 | LTA4H (0.67) | LTA4HMMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |