Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 9/20 | 0.45 |
| ▸ | CA2 | P00918 | 9/20 | 0.45 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264039 | 1.00 | CA14 (0.58) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL5919555 | 0.97 | CA14 (0.58) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL7631999 | 0.97 | CA14 (0.62) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL19340291 | 0.96 | CA14 (0.57) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL3472122 | 0.94 | CA14 (0.62) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL1919913 | 0.93 | CA14 (0.60) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL10181287 | 0.93 | CA14 (0.53) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL4370840 | 0.93 | CA14 (0.59) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL18258336 | 0.92 | CA14 (0.53) | CA14TDP1MAOAMAOBMEN1 | |
| SCHEMBL13055412 | 0.91 | CA14 (0.64) | CA14TDP1MAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730902-B2 | Polyamine transport inhibitors as novel therapeutics | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730902-B2 | Polyamine transport inhibitors as novel therapeutics | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730902-B2 | Polyamine transport inhibitors as novel therapeutics | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9598351-B2 | Polyamine transporter selective compounds as anti-cancer agents | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20160151312-A1 | POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-06-02 | — | — | US | disclosed |
| US-20160151312-A1 | POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-06-02 | — | — | US | disclosed |
| US-9212131-B2 | Polyamine transport inhibitors as novel therapeutics | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212131-B2 | Polyamine transport inhibitors as novel therapeutics | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-9150495-B2 | Polyamine transporter selective compounds as anti cancer agents | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140057989-A1 | POLYAMINE TRANSPORTER SELECTIVE COMPOUNDS AS ANTI CANCER AGENTS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-8497398-B1 | Polyamine transporter selective compounds as anti-cancer agents | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120172449-A1 | POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2012-07-05 | — | — | US | disclosed |
| US-20120172449-A1 | POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2012-07-05 | — | — | US | disclosed |
| US-7910363-B1 | Lipophilic polyamines providing enhanced intracellular delivery of agents by a polyamine transport system | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160151312-A1 | POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS | SLC19A1, SLC75A1, SLC46A1 | CA14 4640/4885TDP1 1799/4885MAOA 521/4885 |
| US-20120172449-A1 | POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS | SLC19A1, SLC75A1, SLC46A1 | CA14 4640/4885TDP1 1799/4885MAOA 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.