Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7270162 | 1.00 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KDM4ETSHRGAA | |
| Acetic Acid SCHEMBL5720116 | 0.90 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4ETSHRGAA | |
| SCHEMBL130070 | 0.88 | KCNN4 (0.41) | ALDH1A1SMN1; SMN2KDM4ETSHRGAA | |
| Bromide SCHEMBL1261498 | 0.87 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4ETSHRGAA | |
| Hydrochloric Acid SCHEMBL173850 | 0.87 | ATM (0.42) | ALDH1A1SMN1; SMN2KDM4ETSHRGAA | |
| SCHEMBL9567759 | 0.83 | HTT (0.41) | ALDH1A1SMN1; SMN2KDM4ETSHRGAA | |
| SCHEMBL5970340 | 0.78 | CYP2C19 (0.48) | ALDH1A1CYP2C19HIF1AADAMTS4ADAMTS5 | |
| SCHEMBL7735572 | 0.76 | GAA (0.36) | ALDH1A1SMN1; SMN2KDM4EGAACYP2C19 | |
| SCHEMBL2678003 | 0.76 | DPP4 (0.54) | CYP2C19HIF1AADAMTS4ADAMTS5DPP4 | |
| Ditiocarb SCHEMBL10336216 | 0.75 | GAA (0.40) | ALDH1A1SMN1; SMN2KDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326977-A | Liquid antiseptic cleaners with improved foaming properties | BASF WYANDOTTE CORPORATION (US) | 1982-04-27 | — | — | US | claimed |
| US-6656919-B1 | Method and a product for the rapid decontamination and sterilization of bacterial endospores | BAUGH CLARENCE L (US) | 2003-12-02 | — | — | US | disclosed |
| WO-2000017303-A1 | ACIDIC HARD SURFACE CLEANING COMPOSITIONS | RECKITT BENCKISER INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| US-4326977-A | Liquid antiseptic cleaners with improved foaming properties | BASF WYANDOTTE CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |