Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270164 | 0.84 | REN (0.52) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7269096 | 0.72 | REN (0.38) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7424256 | 0.71 | REN (0.41) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9740699 | 0.71 | REN (0.41) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9740697 | 0.71 | REN (0.41) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7298899 | 0.70 | REN (0.37) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7268135 | 0.68 | REN (0.49) | REN | |
| SCHEMBL9740589 | 0.68 | REN (0.54) | REN | |
| SCHEMBL7269394 | 0.68 | REN (0.49) | REN | |
| SCHEMBL9725802 | 0.68 | REN (0.49) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |