Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270160 | 0.84 | REN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7269155 | 0.81 | REN (0.44) | REN | |
| SCHEMBL7269158 | 0.81 | REN (0.44) | REN | |
| SCHEMBL7269862 | 0.80 | REN (0.45) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9740591 | 0.80 | REN (0.54) | REN | |
| SCHEMBL9740589 | 0.80 | REN (0.54) | REN | |
| SCHEMBL7277296 | 0.78 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7277290 | 0.78 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7269941 | 0.78 | CTSD (0.43) | REN | |
| SCHEMBL7268135 | 0.77 | REN (0.49) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |