Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398195 | 0.83 | ALDH1A1 (0.50) | CYP2D6HTR2AMAPTALDH1A1LMNA | |
| SCHEMBL20921224 | 0.83 | ALDH1A1 (0.50) | CYP2D6HTR2AMAPTALDH1A1LMNA | |
| SCHEMBL1702059 | 0.83 | HTT (0.46) | SLC6A2SLC6A4CYP2D6SLC6A3HTR2A | |
| SCHEMBL7271568 | 0.83 | HTT (0.36) | SLC6A2SLC6A4CYP2D6SLC6A3HTR2A | |
| SCHEMBL11211947 | 0.83 | HTR2A (0.53) | SLC6A2SLC6A4CYP2D6HTR2AHRH1 | |
| SCHEMBL17193848 | 0.82 | LMNA (0.40) | SLC6A2SLC6A4CYP2D6SLC6A3ALDH1A1 | |
| SCHEMBL9683908 | 0.82 | LMNA (0.40) | SLC6A2SLC6A4CYP2D6SLC6A3ALDH1A1 | |
| SCHEMBL17193849 | 0.82 | LMNA (0.40) | SLC6A2SLC6A4CYP2D6SLC6A3ALDH1A1 | |
| SCHEMBL5497052 | 0.81 | HTT (0.45) | SLC6A2SLC6A4CYP2D6HTR2AALDH1A1 | |
| SCHEMBL7405300 | 0.79 | HTR2A (0.50) | SLC6A2SLC6A4CYP2D6HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428940-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | BEECHAM GROUP P.L.C. (GB) | 1984-01-31 | — | — | US | disclosed |
| EP-0060668-A1 | N-carboxyalkyl dipeptide derivatives and pharmaceutical compositions thereof | BEECHAM GROUP PLC (GB) | 1982-09-22 | — | — | EP | disclosed |