Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 4/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270796 | 1.00 | ALDH1A1 (0.74) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL12646713 | 0.86 | ALDH1A1 (0.72) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL14865943 | 0.86 | ALDH1A1 (0.72) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL392680 | 0.85 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL30216480 | 0.85 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL4861809 | 0.85 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL478614 | 0.85 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7840775 | 0.84 | ALDH1A1 (0.97) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL4800642 | 0.83 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL4797064 | 0.83 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580999-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-12-03 | — | — | US | disclosed |
| US-5571920-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0432694-B1 | Aminoalcohols | HOFFMANN LA ROCHE (CH) | 1996-05-29 | — | — | EP | disclosed |
| US-5516913-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5508430-A | Oxirane intermediates for novel alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5488115-A | Alcohols | HOFFMANN-LA ROCHE INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451678-A | Intermediates for viricides | HOFFMANN-LA ROCHE INC. (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0657419-A1 | Alcohols | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |
| EP-0432694-A2 | Aminoalcohols | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-19 | — | — | EP | disclosed |