Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271878 | 0.86 | PDE5A (0.57) | KDM4EALDH1A1HPGDPDE5AFGFR1 | |
| Hydrochloric Acid SCHEMBL7278102 | 0.84 | PDE5A (0.58) | KDM4EALDH1A1HPGDPDE5AFGFR1 | |
| SCHEMBL7270959 | 0.84 | PDE2A (0.58) | KDM4EALDH1A1HPGDPDE5APDE3B | |
| SCHEMBL7272003 | 0.83 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDPDE5AFGFR1 | |
| Hydrochloric Acid SCHEMBL7272531 | 0.83 | PDE2A (0.57) | KDM4EALDH1A1HPGDPDE5APDE3B | |
| SCHEMBL7281035 | 0.81 | PDE5A (0.55) | KDM4EALDH1A1HPGDPDE5APDE3B | |
| Hydrochloric Acid SCHEMBL10844959 | 0.80 | PDE5A (0.56) | KDM4EALDH1A1HPGDPDE5APDE3B | |
| Hydrochloric Acid SCHEMBL7272791 | 0.80 | PDE5A (0.56) | KDM4EALDH1A1HPGDPDE5APDE3B | |
| SCHEMBL7272579 | 0.79 | PDE5A (0.56) | KDM4EALDH1A1HPGDPDE5APDE3B | |
| SCHEMBL10869519 | 0.78 | PDE5A (0.59) | KDM4EALDH1A1HPGDPDE5APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4904785-A | INOTROPIC AGENTS FOR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1990-02-27 | — | — | US | disclosed |
| US-4758574-A | 2-phenylimidazio (4,5-c) pyridines | ELI LILLY AND COMPANY (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0093593-A2 | Pyridine compounds | ELI LILLY AND COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |