Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 5/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1439921 | 0.86 | MTNR1A (0.44) | APPKDM4EMTNR1AMTNR1BHPGD | |
| SCHEMBL423324 | 0.78 | CYP1A2 (0.59) | NCF1KDM4EHPGDALDH1A1CYP1A2 | |
| SCHEMBL30081479 | 0.77 | BACE1 (0.53) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL727654 | 0.77 | BACE1 (0.53) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL19330216 | 0.77 | HTR3A (0.45) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL29768705 | 0.77 | ESR1 (0.50) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL1238150 | 0.77 | ESR1 (0.50) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL7270869 | 0.77 | NCF1 (0.41) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL21698711 | 0.77 | KDM4E (0.58) | NCF1KDM4ENQO1HDAC3HDAC4 | |
| SCHEMBL16751340 | 0.76 | PDE10A (0.46) | KDM4EMTNR1AMTNR1BHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4710507-A | Quinolone inotropic agents | PFIZER INC. (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0148623-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1985-07-17 | — | — | EP | disclosed |