Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | UTRN | P46939 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9361685 | 0.74 | PDE10A (0.44) | UTRNKDM5B | |
| SCHEMBL10771601 | 0.70 | PDE4A (0.53) | CYP1A2CYP3A4CYP2C19ALDH1A1KDM4E | |
| SCHEMBL30743 | 0.69 | NPC1 (1.00) | NPC1POLBRAB9ADYRK1AMAPT | |
| SCHEMBL29757180 | 0.69 | NPC1 (1.00) | NPC1POLBRAB9ADYRK1AMAPT | |
| SCHEMBL20371603 | 0.67 | RAB9A (0.61) | NPC1POLBRAB9ADYRK1AMAPT | |
| SCHEMBL14741278 | 0.67 | MCL1 (0.53) | NPC1POLBRAB9AMAPTCYP1A2 | |
| SCHEMBL1150800 | 0.66 | NPC1 (0.54) | NPC1POLBRAB9ADYRK1AMAPT | |
| SCHEMBL2502604 | 0.66 | TOP2A (0.49) | DYRK1ACYP1A2KDM5B | |
| SCHEMBL11833 | 0.65 | ALDH1A1 (0.58) | NPC1POLBRAB9ADYRK1AMAPT | |
| SCHEMBL9710552 | 0.65 | ADH5 (0.52) | CYP1A2CYP3A4CYP2C19TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365863-B1 | Novel quinolyloxazole-2-ones useful as proteinkinase C inhibitors | MERRELL DOW PHARMA (US) | 1994-08-17 | — | — | EP | disclosed |
| EP-0428105-B1 | Use of quinolyl- and isoquinolyloxazole-2-ones for the production of a medicament for the prevention of glycoprotein enveloped virus infectivity | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| EP-0428107-B1 | Use of quinolyl-and isoquinolyloxanole-2-ones for the production of a medicament for the treatment of multi-drug resistant tumors | MERRELL DOW PHARMA (US) | 1994-01-19 | — | — | EP | disclosed |
| US-4999431-A | Reacting A Bromoquinoline Compound With Butyllithium And An N-Methyl-N-Methoxyalkanamide; Intermediates for Quinolyloxazole-2-ones | MERRELL DOW PHARMACEUTICALS (US) | 1991-03-12 | — | — | US | disclosed |
| US-4990519-A | Antiasthma, hypotensive agents, bronchodilator agents | MERRELL DOW PHARMACEUTICALS (US) | 1991-02-05 | — | — | US | disclosed |
| US-4886811-A | HYPOTENSIVE AGENTS AND VASODILATORS | MERRELL DOW PHARMACEUTICALS (US) | 1989-12-12 | — | — | US | disclosed |