Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272955 | 0.93 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAAHPGDGLA | |
| SCHEMBL7278704 | 0.89 | ALDH1A1 (0.44) | ALDH1A1KDM4EGAAHPGDGLA | |
| SCHEMBL7278440 | 0.86 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAAHPGDGLA | |
| SCHEMBL7278351 | 0.82 | CYP2C9 (0.41) | ALDH1A1KDM4EHPGDCASP1HSD17B10 | |
| SCHEMBL7278457 | 0.78 | ADORA3 (0.41) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL7278442 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAHPGDGLA | |
| SCHEMBL7273553 | 0.74 | ADORA3 (0.60) | ALDH1A1KDM4EHPGDHSD17B10CYP1A2 | |
| SCHEMBL7280554 | 0.74 | LMNA (0.43) | ALDH1A1HPGDHSD17B10KMT2ANPSR1 | |
| SCHEMBL7271011 | 0.73 | CACNA1C (0.44) | ALDH1A1KDM4EGAACYP1A2CYP3A4 | |
| SCHEMBL7279034 | 0.73 | LMNA (0.52) | ALDH1A1KDM4EGAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |