Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.72 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.72 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.72 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.72 |
| ▸ | GABRP | O00591 | 2/20 | 0.72 |
| ▸ | GABRD | O14764 | 2/20 | 0.72 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.72 |
| ▸ | GABRE | P78334 | 2/20 | 0.72 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.72 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.72 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.72 |
| ▸ | GRM5 | P41594 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10569670 | 0.88 | GABRG2 (0.72) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10626578 | 0.87 | GABRG2 (0.55) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10572044 | 0.86 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7390365 | 0.86 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10573210 | 0.85 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7279375 | 0.83 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10570779 | 0.83 | GABRA1 (0.70) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10963571 | 0.82 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9869693 | 0.82 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10962583 | 0.82 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787729-B1 | A process for the manufacture of imidazodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2001-04-18 | — | — | EP | claimed |
| EP-0787729-A2 | A process for the manufacture of imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-08-06 | — | — | EP | claimed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | claimed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | claimed |
| EP-0672666-B1 | Imidazodiazepins | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | EP | disclosed |
| EP-0787729-B1 | A process for the manufacture of imidazodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2001-04-18 | — | — | EP | disclosed |
| CN-1046519-C | Oxazolyl-and thiazolylimidazo- and thienodiazepines and their use as medicaments | HOFFMANN LA ROCHE (CH) | 1999-11-17 | — | — | CN | disclosed |
| CN-1167487-A | Oxazolyl-and thiazolyl-imidazo-benzo-and thienodiazepine * and their use as pharmaceuticals | HOFFMANN LA ROCHE (CH) | 1997-12-10 | — | — | CN | disclosed |
| US-5665718-A | ANXIOLYTIC, ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE, HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0790999-A1 | OXAZOLYL- AND THIAZOLYLIMIDAZO-BENZO- AND THIENODIAZEPINES AND THEIR USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-08-27 | — | — | EP | disclosed |
| EP-0787729-A2 | A process for the manufacture of imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996015129-A1 | OXAZOLYL- AND THIAZOLYLIMIDAZO-BENZO- AND THIENODIAZEPINES AND THEIR USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-05-23 | — | — | WO | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346035-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346030-A | ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |