Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.63 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.63 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.63 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.63 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.63 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.63 |
| ▸ | GABRP | O00591 | 2/20 | 0.63 |
| ▸ | GABRD | O14764 | 2/20 | 0.63 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.63 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.63 |
| ▸ | GABRE | P78334 | 2/20 | 0.63 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.63 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.63 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.63 |
| ▸ | GRM5 | P41594 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963571 | 0.85 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10962583 | 0.85 | GABRG2 (0.63) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7271368 | 0.83 | GABRG2 (0.61) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL27841674 | 0.82 | GABRG2 (0.61) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7271107 | 0.82 | GABRG2 (0.72) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7332740 | 0.82 | GABRA1 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL11217198 | 0.82 | GABRG2 (0.64) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10569670 | 0.82 | GABRG2 (0.72) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9869532 | 0.82 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10625704 | 0.81 | GABRA1 (0.72) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021411-A | Tranquilizers, anticonvulsants | HOFFMANN-LA ROCHE INC. (US) | 1991-06-04 | — | — | US | disclosed |
| US-4863920-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1989-09-05 | — | — | US | disclosed |