Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | MECP2 | P51608 | 1/20 | 0.36 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269824 | 1.00 | ALDH1A1 (0.43) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL7269831 | 1.00 | ALDH1A1 (0.43) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL3623346 | 0.86 | HSD17B10 (0.56) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL11441332 | 0.84 | ALDH1A1 (0.41) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL7276567 | 0.83 | GAA (0.60) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL2362161 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL17634089 | 0.80 | TP53 (0.46) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL7270932 | 0.73 | SLC6A3 (0.39) | ALDH1A1SMN1; SMN2SLC6A3GSK3BBCHE | |
| SCHEMBL7271513 | 0.73 | SLC6A3 (0.39) | ALDH1A1SMN1; SMN2SLC6A3GSK3BBCHE | |
| SCHEMBL7277465 | 0.73 | SLC6A3 (0.39) | ALDH1A1SMN1; SMN2SLC6A3GSK3BBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441539-B1 | Thiazine (or oxazine) derivatives and preparation thereof | TANABE SEIYAKU CO (JP) | 1996-04-10 | — | — | EP | disclosed |
| US-5496815-A | TREATMENT OF ISCHEMIC ENCEPHALOPATHIA | TANABE SEIYAKU CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| CN-1029963-C | Process for preparing benzo-naphtho-derivatives of thiazines or oxazines | TANABE SEIYAKU CO (JP) | 1995-10-11 | — | — | CN | disclosed |
| US-5281592-A | Calcium antagonist, antiischemic agents, brains, nervous system disorders | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| US-5246929-A | Prophylaxis or treatment of ischemic encephalopathia | TANABE SEIYAKU CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| CN-1054065-A | Thiazine or oxazine derivative and preparation method thereof | TANABE SEIYAKU CO (JP) | 1991-08-28 | — | — | CN | disclosed |
| EP-0441539-A2 | Thiazine (or oxazine) derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |