Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | MECP2 | P51608 | 1/20 | 0.32 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270932 | 1.00 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4ARKDM4E | |
| SCHEMBL7271513 | 1.00 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4ARKDM4E | |
| SCHEMBL7271246 | 0.73 | ALDH1A1 (0.43) | SLC6A3SLC6A2KDM4ENPSR1ALDH1A1 | |
| SCHEMBL7269824 | 0.73 | ALDH1A1 (0.43) | SLC6A3SLC6A2KDM4ENPSR1ALDH1A1 | |
| SCHEMBL7269831 | 0.73 | ALDH1A1 (0.43) | SLC6A3SLC6A2KDM4ENPSR1ALDH1A1 | |
| SCHEMBL7276863 | 0.73 | CA2 (0.41) | SLC6A3SLC6A2SLC6A4ARKDM4E | |
| SCHEMBL1790645 | 0.65 | ALDH1A1 (0.41) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL7271098 | 0.65 | PPARG (0.49) | NPSR1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL11316344 | 0.63 | TAAR1 (0.38) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL1808446 | 0.63 | ALDH1A1 (0.38) | KDM4ENPSR1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441539-B1 | Thiazine (or oxazine) derivatives and preparation thereof | TANABE SEIYAKU CO (JP) | 1996-04-10 | — | — | EP | disclosed |
| US-5496815-A | TREATMENT OF ISCHEMIC ENCEPHALOPATHIA | TANABE SEIYAKU CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5281592-A | Calcium antagonist, antiischemic agents, brains, nervous system disorders | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| US-5246929-A | Prophylaxis or treatment of ischemic encephalopathia | TANABE SEIYAKU CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0441539-A2 | Thiazine (or oxazine) derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |