Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.49 |
| ▸ | REN | P00797 | 4/20 | 0.45 |
| ▸ | METAP2 | P50579 | 5/20 | 0.42 |
| ▸ | METAP1 | P53582 | 3/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10408931 | 1.00 | CTSD (0.49) | CTSDRENMETAP2METAP1CPB2 | |
| SCHEMBL9831134 | 0.84 | REN (0.51) | CTSDRENMETAP2METAP1CPB2 | |
| SCHEMBL10608625 | 0.84 | REN (0.51) | CTSDRENMETAP2METAP1CPB2 | |
| Hydrochloric Acid SCHEMBL9832396 | 0.82 | REN (0.50) | CTSDRENMETAP2METAP1CPB2 | |
| SCHEMBL7284052 | 0.81 | REN (0.47) | CTSDRENMETAP2METAP1CPB2 | |
| SCHEMBL7272512 | 0.78 | REN (0.48) | CTSDRENMETAP2METAP1CPB2 | |
| Acetic Acid SCHEMBL7273055 | 0.78 | REN (0.45) | RENMETAP2METAP1CPB2 | |
| SCHEMBL10606263 | 0.77 | CTSD (0.44) | CTSDRENMETAP2METAP1CPB2 | |
| SCHEMBL9833496 | 0.77 | CTSD (0.44) | CTSDRENMETAP2METAP1CPB2 | |
| Acetic Acid SCHEMBL7294621 | 0.77 | REN (0.46) | CTSDRENMETAP2METAP1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0483271-B1 | PEPTIDES CONTAINING DIAMINO-GLYCOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1993-08-25 | — | — | EP | disclosed |
| EP-0552247-A1 | PEPTIDES CONTAINING SUBSTITUTED 1,4-DIAMINES AS TRANSITION-STATE INSERTS | THE UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0546115-A1 | PEPTIDES CONTAINING AMINO-POLYOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |
| WO-1992006996-A1 | PEPTIDES CONTAINING SUBSTITUTED 1,4-DIAMINES AS TRANSITION-STATE INSERTS | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |
| WO-1992003472-A1 | PEPTIDES CONTAINING AMINO-POLYOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1992-03-05 | — | — | WO | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |
| WO-1991001327-A1 | PEPTIDES CONTAINING DIAMINO-GLYCOLS AS TRANSITION-STATE MIMICS | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4927807-A | RENIN INHIBITING AMIDES | ABBOTT LABORATORIES (US) | 1990-05-22 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |