Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 5/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263755 | 0.95 | CYP2C9 (0.42) | DGAT1NPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL7265522 | 0.87 | CYP2C9 (0.42) | DGAT1NPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL10863492 | 0.87 | CYP2C9 (0.40) | DGAT1NPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL10999485 | 0.87 | CYP2C9 (0.48) | DGAT1NPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL7272935 | 0.87 | ADORA3 (0.46) | NPC1RAB9AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7265676 | 0.86 | ALDH1A1 (0.38) | MAPK1L3MBTL1HTTCYP2C9KDM4E | |
| SCHEMBL7264441 | 0.86 | CYP2C9 (0.37) | DGAT1NPC1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL10366682 | 0.85 | CYP2C9 (0.40) | DGAT1NPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL7271627 | 0.84 | CYP2C9 (0.47) | L3MBTL1HTTCYP2C9KDM4EMEN1 | |
| SCHEMBL11001087 | 0.82 | CYP2C9 (0.56) | DGAT1NPC1RAB9AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |