Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992645 | 0.88 | ADORA3 (0.60) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL7265665 | 0.87 | MAPT (0.51) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL7271783 | 0.87 | DGAT1 (0.40) | ADORA3ABCB11LMNACYP1A2SCN1A | |
| SCHEMBL7263755 | 0.85 | CYP2C9 (0.42) | ADORA3ABCB11LMNACYP1A2SCN1A | |
| SCHEMBL7271902 | 0.85 | PDE1C (0.48) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL7273125 | 0.80 | LMNA (0.47) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL10369519 | 0.80 | ADORA3 (0.58) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL11359797 | 0.79 | CACNA1D (0.53) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL6427770 | 0.78 | ADORA3 (0.67) | ADORA3ABCC4CACNA1FABCB11LMNA | |
| SCHEMBL10646965 | 0.78 | CACNA1D (0.56) | ADORA3ABCC4CACNA1FABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |