Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280864 | 0.90 | LMNA (0.43) | TACR1MAPTTDP1KDM4ECA1 | |
| SCHEMBL7353357 | 0.90 | LMNA (0.43) | TACR1MAPTTDP1KDM4ECA1 | |
| SCHEMBL729057 | 0.85 | LTA4H (0.44) | TACR1MAPTALDH1A1LTA4HLAP3 | |
| SCHEMBL713212 | 0.85 | LTA4H (0.44) | TACR1MAPTALDH1A1LTA4HLAP3 | |
| P-Toluenesulfonamide SCHEMBL8729542 | 0.85 | LMNA (0.43) | TACR1MAPTCA1LMNA | |
| Hydrochloric Acid SCHEMBL9515675 | 0.84 | LTA4H (0.43) | TACR1MAPTALDH1A1LTA4HLAP3 | |
| Hydrochloric Acid SCHEMBL9515682 | 0.84 | LTA4H (0.43) | TACR1MAPTALDH1A1LTA4HLAP3 | |
| Hydrochloric Acid SCHEMBL7273689 | 0.84 | LTA4H (0.43) | TACR1MAPTALDH1A1LTA4HLAP3 | |
| Hydrochloric Acid SCHEMBL7273682 | 0.84 | LTA4H (0.43) | TACR1MAPTALDH1A1LTA4HLAP3 | |
| Histidine SCHEMBL27960814 | 0.76 | SLC7A5 (0.43) | POLBMAPTKDM4ELMNACASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4636567-A | CNS DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1987-01-13 | — | — | US | disclosed |
| US-4610821-A | CENTRAL NERVOUS SYSTEM, THYROTROPIN RELEASING HORMONE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-09-09 | — | — | US | disclosed |
| US-4564609-A | NERVOUS SYSTEM DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-01-14 | — | — | US | disclosed |
| EP-0123444-A1 | 4-Substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1984-10-31 | — | — | EP | disclosed |