Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270867 | 0.80 | PIK3CD (0.47) | HPGDCYP2D6ADORA1PDGFRBPDGFRA | |
| SCHEMBL15344999 | 0.77 | HPGD (0.46) | HPGDADORA1PDGFRBPDGFRAMAOA | |
| SCHEMBL29941357 | 0.75 | CYP19A1 (0.56) | CYP2D6PDGFRBPDGFRACYP19A1MAPK1 | |
| SCHEMBL7270915 | 0.74 | ADORA1 (0.42) | HPGDADORA1PDGFRBPDGFRACLK1 | |
| SCHEMBL26632728 | 0.74 | NPC1 (0.65) | HPGDPDGFRBPDGFRAGSK3BCYP3A4 | |
| SCHEMBL30629466 | 0.74 | NPC1 (0.65) | HPGDPDGFRBPDGFRAGSK3BCYP3A4 | |
| SCHEMBL15341950 | 0.74 | HPGD (0.41) | HPGDADORA1PDGFRBPDGFRACLK1 | |
| SCHEMBL7264558 | 0.72 | CYP11B2 (0.64) | PDGFRBPDGFRACYP19A1CDK5CDK9 | |
| SCHEMBL12695592 | 0.72 | BACE1 (0.57) | HPGDADORA1PDGFRBPDGFRACYP19A1 | |
| SCHEMBL16573997 | 0.72 | PDGFRB (0.46) | HPGDADORA1PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4710507-A | Quinolone inotropic agents | PFIZER INC. (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0148623-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1985-07-17 | — | — | EP | disclosed |