Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264558 | 0.75 | CYP11B2 (0.64) | PDE10APDE2ACYP17A1CYP11B2CYP19A1 | |
| SCHEMBL12695592 | 0.75 | BACE1 (0.57) | ADORA1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL15344999 | 0.74 | HPGD (0.46) | ADORA1HPGDNPC1RAB9APDE10A | |
| SCHEMBL7272115 | 0.74 | HPGD (0.43) | ADORA1HPGDCYP19A1GSK3BDYRK1A | |
| SCHEMBL7270867 | 0.74 | PIK3CD (0.47) | ADORA1HPGDCYP17A1CYP11B2CYP19A1 | |
| SCHEMBL7272193 | 0.74 | PDGFRB (0.41) | ADORA1HPGDCYP17A1CYP11B2CYP19A1 | |
| SCHEMBL7345238 | 0.73 | PDE10A (0.52) | ADORA1HPGDDHODHNPC1RAB9A | |
| SCHEMBL16573997 | 0.72 | PDGFRB (0.46) | ADORA1HPGDNPC1RAB9APDE10A | |
| SCHEMBL27736352 | 0.72 | ALDH1A1 (0.50) | HPGDKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15341950 | 0.71 | HPGD (0.41) | ADORA1HPGDKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4710507-A | Quinolone inotropic agents | PFIZER INC. (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0148623-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1985-07-17 | — | — | EP | disclosed |