Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | SCN1A | P35498 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281470 | 0.92 | CACNA1C (0.50) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7278723 | 0.91 | ADORA3 (0.62) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL10377480 | 0.90 | ADORA3 (0.46) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7282331 | 0.89 | ACHE (0.56) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7280852 | 0.89 | KMT2A (0.49) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7271737 | 0.87 | ACHE (0.55) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7272932 | 0.87 | CACNA1C (0.53) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7271051 | 0.86 | ACHE (0.53) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7280765 | 0.86 | CACNA1D (0.54) | ACHECACNA1DCACNA1CCACNA1FCACNA1S | |
| SCHEMBL7271021 | 0.84 | CACNA1D (0.54) | ACHECACNA1DCACNA1CCACNA1FCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361382-B1 | ANTIEPILEPTIC PYRAZOLOPYRIDINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-16 | — | — | EP | disclosed |
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| US-4916140-A | CALCIUM CHANNEL BLOCKERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0361382-A2 | Antiepileptic pyrazolopyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-04 | — | — | EP | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |