Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 4/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272599 | 0.91 | CACNA1D (0.49) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL7282275 | 0.88 | CA1 (0.49) | CACNA1CCACNA1DCACNA1FCACNA1SCA1 | |
| SCHEMBL7272365 | 0.87 | ACHE (0.53) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL7271096 | 0.84 | CA1 (0.46) | CACNA1CCACNA1DCACNA1FCACNA1SCA1 | |
| SCHEMBL7280226 | 0.81 | ACHE (0.52) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL7282043 | 0.79 | CACNA1F (0.64) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL7281470 | 0.79 | CACNA1C (0.50) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL7278639 | 0.78 | TSHR (0.52) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL10377480 | 0.77 | ADORA3 (0.46) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 | |
| SCHEMBL7278723 | 0.77 | ADORA3 (0.62) | CACNA1CCACNA1DCACNA1FCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361382-B1 | ANTIEPILEPTIC PYRAZOLOPYRIDINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-16 | — | — | EP | disclosed |
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| US-4916140-A | CALCIUM CHANNEL BLOCKERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0361382-A2 | Antiepileptic pyrazolopyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-04 | — | — | EP | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |